Summary of project PR001815
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001815. The data can be accessed directly via it's Project DOI: 10.21228/M83Q7Q This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR001815 |
| Project DOI: | doi: 10.21228/M83Q7Q |
| Project Title: | Metabolomic Characteristics of Nontuberculous Mycobacterial Pulmonary Disease |
| Project Summary: | While the burden of nontuberculous mycobacterial pulmonary disease (NTM-PD) continues to increase, knowledge of biomarkers for NTM-PD remains insufficient. Furthermore, metabolic changes in NTM-PD have not yet been investigated. The identification of specific metabolites and associated metabolic pathways unique to NTM-PD will provide a deeper understanding of its pathogenesis. In this study, we aimed to discover specific metabolic biomarkers for NTM-PD using a metabolomics approach. In this study, we underwent untargeted metabolomic profiling using a liquid chromatography system coupled with the quadrupole-orbitrap mass spectrometer to analyze serum samples from patients with NTM-PD (n = 50), patients with non-NTM bronchiectasis (n = 50), and HC subjects (n = 60). To validate the results, an additional 86 serum samples for each group were analyzed using the same analytical methods. We identified several NTM-PD significant metabolites that differentiate patients with NTM-PD from healthy individuals. The machine learning-based classification model demonstrated the proficiency of the selected metabolic features in distinguishing between patients with NTM-PD and healthy individuals. These findings may contribute to a better understanding of the pathogenesis of NTM-PD and provide insights for the development of novel treatment approaches. |
| Institute: | Seoul National University College of Medicine and Hospital |
| Department: | Department of Clinical Pharmacology and Therapeutics |
| Last Name: | Jungeun |
| First Name: | Kim |
| Address: | 101 Daehak-ro, Jongno-gu, Seoul, Korea |
| Email: | jeunk@snu.ac.kr |
| Phone: | +821026965910 |
Summary of all studies in project PR001815
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST002921 | Metabolomic Characteristics of Nontuberculous Mycobacterial Pulmonary Disease | Homo sapiens | Seoul National University College of Medicine and Hospital | MS* | 2024-01-31 | 1 | 418 | Uploaded data (23.1G)* |
