Summary of project PR001838
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001838. The data can be accessed directly via it's Project DOI: 10.21228/M84H8B This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR001838 |
| Project DOI: | doi: 10.21228/M84H8B |
| Project Title: | Viremic non-progressors evade HIV-1 pathogenesis by CCR5Δ32 heterozygosity, low activation of cytotoxic cells and reduced IFN response |
| Project Summary: | Viremic Non-Progressors (VNPs) maintain normal CD4+ T-cell counts despite uncontrolled HIV-1 replication, but mechanisms leading to CD4+ T-cell preservation are incompletely characterized. We aim to generate a comprehensive understanding of this infrequent phenotype by comparing rates of cellular infection, immunophenotype, genomics, single-cell transcriptomics, metabolomics, and levels of plasma biomarkers in 16 VNPs and 29 HIV+ Progressors. During chronic infection VNPs show lower frequency of HIV-1-infected cells in periphery, which is associated with reduced CCR5 expression and higher prevalence of CCR5Δ32 heterozygosity. The CD8+ T-cell compartment displays a less cytotoxic and less activated phenotype in VNPs. Moreover, despite similar viremia, we found lower bystander CD4+ T-cell death in the VNPs, together with weaker IFN responses, reduced plasma levels of zonulin (a biomarker of intestinal permeability), altered tryptophan catabolism, and preserved LPS responsiveness in vitro. Overall, a complex multifactorial mechanism, suggesting gut-associated lymphoid tissue preservation, underlies resistance to HIV pathogenesis in VNPs. |
| Institute: | IrsiCaixa |
| Last Name: | Martinez-Picado |
| First Name: | Javier |
| Address: | Carretera de Canyet, s/n, 08916 Badalona, Barcelona |
| Email: | jmpicado@irsicaixa.es |
| Phone: | +34 934 65 63 74 |
Summary of all studies in project PR001838
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST002955 | Untargeted metabolomics analysis of plasma from viremic non-progressors (VNP), progressors, and healthy control (HC) patients using high-resolution, high-performance LC-MS/MS analysis. | Homo sapiens | IrsiCaixa | MS | 2024-10-16 | 1 | 51 | Uploaded data (7.5G)* |
