Summary of project PR001842
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001842. The data can be accessed directly via it's Project DOI: 10.21228/M8MH8P This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR001842 |
| Project DOI: | doi: 10.21228/M8MH8P |
| Project Title: | Mid-Old Cells are Potential Target for Anti-aging Interventions in the Elderly |
| Project Summary: | The biological process of aging is thought to result in part from accumulation of senescent cells in organs. However, the present study identified a subset of fibroblasts and smooth muscle cells which are the major constituents of organ stroma neither proliferative nor senescent in tissues of the elderly, which we termed “mid-old status” cells. Upregulation of pro-inflammatory genes (IL1B and SAA1) and downregulation of anti-inflammatory genes (SLIT2 and CXCL12) were detected in mid-old cells. In the stroma, SAA1 promotes development of the inflammatory microenvironment via upregulation of MMP9, which decreases the stability of epithelial cells present on the basement membrane, decreasing epithelial cell function. Remarkably, the microenvironmental change and the functional decline of mid-old cells could be reversed by a young cell-originated protein, SLIT2. Our data identify functional reversion of mid-old cells as a potential method to prevent or ameliorate aspects of aging-related tissue dysfunction. |
| Institute: | Ajou University Medical Center |
| Last Name: | Kim |
| First Name: | Young Hwa |
| Address: | 206, World cup-ro, Yeongtong-gu, Suwon-si, Gyeonggi-do, Republic of Korea |
| Email: | skyblue32@nate.com |
| Phone: | +82-10-5153-3636 |
Summary of all studies in project PR001842
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST002960 | Analysis of Lipids Secreted from Fibroblast Young Cells | Homo sapiens | Ajou University Medical Center | MS* | 2023-11-22 | 1 | 6 | Uploaded data (861.7M)* |
| ST002961 | Analysis of Metabolites Secreted from Fibroblast Young Cells | Homo sapiens | Ajou University Medical Center | MS* | 2023-11-22 | 1 | 7 | Uploaded data (2.4G)* |
