Summary of project PR001844
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001844. The data can be accessed directly via it's Project DOI: 10.21228/M8C145 This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR001844 |
| Project DOI: | doi: 10.21228/M8C145 |
| Project Title: | Molecular Phenotypes of Null Alleles in Cells |
| Project Summary: | The 2020 NHGRI Strategic Vision laid out a set of “bold predictions for human genomics by 2030” including elucidating the biological function(s) of each human gene. The Molecular Phenotypes of Null Alleles in Cells (MorPhiC) seeks to address this element of the strategic vision. Through the comprehensive generation of null alleles for every human gene and then cataloging the resulting molecular and cellular phenotypes, the mechanisms that relate gene function to observed phenotypes can be determined. Furthermore, the resulting catalog of knockouts and phenotypes will be made available for broader use by the biomedical community. Although multiple approaches can be leveraged to measure molecular and cellular phenotypes resulting from gene knockouts, metabolomics and lipidomics (i.e., biochemical phenotyping) provides an avenue to understand the link between gene function and phenotypes at a molecular level. This project consists of studies performed to biochemical phenotype of cell lines and other samples generated as part of MorPhiC. Resources: 1. https://www.nih.gov/news-events/news-releases/nih-initiative-systematically-investigate-establish-function-every-human-gene 2. https://www.genome.gov/research-funding/Funded-Programs-Projects/Molecular-Phenotypes-of-Null-Alleles-in-Cells |
| Institute: | The Jackson Laboratory for Genomic Medicine |
| Laboratory: | Shuzhao Li Lab |
| Last Name: | Chi |
| First Name: | Yuanye |
| Address: | 10 Discovery Dr, Farmington, CT |
| Email: | yuanye.chi@jax.org |
| Phone: | 3395456866 |
Summary of all studies in project PR001844
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST002964 | Comprehensive Untargeted LC-MS Metabolomics Analysis of CYP19A1/PRLR/PTN Knockout iPSCs | Homo sapiens | Jackson Laboratory for Genomic Medicine | MS* | 2025-05-14 | 1 | 252 | Uploaded data (56.5G)* |
| ST002965 | Comprehensive Untargeted LC-MS Metabolomics Analysis of CYP19A1/PRLR/PTN Knockout iPSCs - Part 2 | Homo sapiens | Jackson Laboratory for Genomic Medicine | MS* | 2025-05-14 | 1 | 252 | Uploaded data (58.1G)* |
| ST003115 | Comprehensive Untargeted LC-MS Metabolomics Analysis of HMGCS2 Knockout iPSCs(Cell Pellet) | Homo sapiens | Jackson Laboratory for Genomic Medicine | MS* | 2025-02-28 | 1 | 146 | Uploaded data (6.2G)* |
| ST003116 | Comprehensive Untargeted LC-MS Metabolomics Analysis of HMGCS2 Knockout iPSCs(Supernatant/Media) | Homo sapiens | Jackson Laboratory for Genomic Medicine | MS* | 2025-02-28 | 1 | 146 | Uploaded data (6.7G)* |
| ST003324 | Comprehensive Untargeted LC-MS Metabolomics Analysis of STS Knockout iPSCs(Cell Pellet) | Homo sapiens | Jackson Laboratory for Genomic Medicine | MS* | 2025-05-14 | 1 | 420 | Uploaded data (20.2G)* |
| ST003325 | Comprehensive Untargeted LC-MS Metabolomics Analysis of STS Knockout iPSCs(Supernatant) | Homo sapiens | Jackson Laboratory for Genomic Medicine | MS* | 2025-05-14 | 1 | 420 | Uploaded data (22.6G)* |
| ST003940 | Comprehensive Untargeted LC-MS Metabolomics Analysis of CYP19A1/SLC22A11/CYP11A1/HSD17B1/ABCG2 Knockout iPSCs | Homo sapiens | The Jackson Laboratory for Genomic Medicine | MS* | 2025-06-09 | 1 | 1528 | Uploaded data (82.6G)* |
| ST003952 | Comprehensive Untargeted LC-MS Metabolomics Analysis of STS/HSD3B1 Knockout iPSCs (supernatant) | Homo sapiens | The Jackson Laboratory for Genomic Medicine | MS* | 2025-06-09 | 1 | 216 | Uploaded data (13.5G)* |
