Summary of project PR001855
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001855. The data can be accessed directly via it's Project DOI: 10.21228/M8XT6T This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR001855 |
| Project DOI: | doi: 10.21228/M8XT6T |
| Project Title: | Integrated multi-omics reveals mTOR-LPL-driven dysregulated lipid metabolism induces neuronal hyperexcitability in human microglia of tuberous sclerosis complex |
| Project Summary: | Tuberous sclerosis complex (TSC) is an autosomal dominant genetic disorder caused by mutations in either TSC1 or TSC2. There's evidence suggests a connection between microglia activation and epilepsy as well as cognitive impairment in TSC patients. However, how the causal variants of TSC1/2 genes identified in TSC patients affect human microglia and how they contribute to the neurological manifestations. This project is focus on this problem using human microglia generated from induced pluripotent stem cells (iPSCs) derived from a TSC patient. |
| Institute: | St Jude Children's Research Hospital |
| Last Name: | Xie |
| First Name: | Boer |
| Address: | 262 Danny Thomas Place, Memphis, TN, 38105, USA |
| Email: | xbr429@gmail.com |
| Phone: | (901) 595-7499 |
Summary of all studies in project PR001855
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST002979 | Untargeted lipidomics profiling of TSC microglia | Homo sapiens | St Jude Children's Research Hospital | MS* | 2023-11-17 | 1 | 26 | Uploaded data (6.1G)* |
