Summary of project PR001862

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001862. The data can be accessed directly via it's Project DOI: 10.21228/M81M8F This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

Project ID: PR001862
Project DOI:doi: 10.21228/M81M8F
Project Title:DNA replication stress underpins the vulnerability to oxidative phosphorylation inhibition in colorectal cancer
Project Summary:Although targeting oxidative phosphorylation (OXPHOS) for cancer treatment is currently impeded due to dose-limiting toxicities, there remain opportunities through combinations that provide therapeutic benefits at doses attainable in patients. On the other hand, while glycolysis-deficient cancers are generally vulnerable to OXPHOS inhibition in preclinical models, the full extent of phenotypical and mechanistic consequences of inhibiting OXPHOS in cancers capable of glycolysis is not yet well understood. We aimed to clarify the response and underlying mechanisms of colorectal cancer (CRC) that commonly exhibit the glycolytic phenotype to OXPHOS inhibition and to identify potential approaches to render such cells more sensitive to OXPHOS inhibitors.
Institute:The University of Newcastle
Last Name:Zhao
First Name:Xiaohong
Address:University Drive, Callaghan, NSW, 2308, Australia
Email:xiaohong.zhao@newcastle.edu.au
Phone:61 0466219528

Summary of all studies in project PR001862

Study IDStudy TitleSpeciesInstituteAnalysis
(* : Contains Untargted data)		 Release
Date		VersionSamplesDownload
(* : Contains raw data)
ST002991 Metabolomics studies on human colorectal cancer cell lines Homo sapiens The University of Newcastle MS 2025-01-13 1 24 Uploaded data (427.6M)*
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