Summary of project PR001901
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001901. The data can be accessed directly via it's Project DOI: 10.21228/M80H83 This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR001901 |
| Project DOI: | doi: 10.21228/M80H83 |
| Project Title: | Synaptic vesicle lipidomics captures signatures of aging and synucleinopathy |
| Project Type: | MS quantitative analysis |
| Project Summary: | Neurotransmitter release occurs through exocytosis of synaptic vesicles. α-Synuclein’s function and dysfunction in Parkinson’s disease and other synucleinopathies is tightly linked to synaptic vesicle binding. Age is the biggest risk factor for synucleinopathy, yet, age- and disease-induced changes in synaptic vesicles remain unexplored. Systematic analysis of the synaptic vesicle lipidome revealed specific changes in two mouse models of synucleinopathy over age. Strikingly, changes in mice lacking α-synuclein were more pronounced than changes in a humanized α-synucleinopathy mouse model, suggesting that loss of α-synuclein function is a major contributor to synaptic dysfunction. These findings not only provide new insights into synaptic vesicle biology and mechanisms of synucleinopathy, but also offer a baseline for further mechanistic exploration of age- and disease-related alterations in synaptic vesicles. |
| Institute: | Weill Cornell Medicine |
| Department: | Brain and Mind Research Institute |
| Laboratory: | Burré lab |
| Last Name: | Burré |
| First Name: | Jacqueline |
| Address: | 413 East 69th Street, BB-1024, New York, NY, 10021, USA |
| Email: | jab2058@med.cornell.edu |
| Phone: | 6469626155 |
Summary of all studies in project PR001901
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST003052 | Synaptic vesicle lipidomics captures signatures of aging and synucleinopathy | Mus musculus | Weill Cornell Medicine | MS* | 2025-04-10 | 1 | 122 | Uploaded data (38.1G)* |
