Summary of project PR001904
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001904. The data can be accessed directly via it's Project DOI: 10.21228/M8M718 This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR001904 |
| Project DOI: | doi: 10.21228/M8M718 |
| Project Title: | Thyroid hormone receptor beta (THRB) dependent regulation of diurnal hepatic lipid metabolism in adult male mice |
| Project Type: | Lipidomics |
| Project Summary: | Thyroid hormones (THs) are critical regulators of systemic energy metabolism and homeostasis. In the liver, high TH action protects against steatosis by enhancing cholesterol and triglyceride turnover, with thyroid hormone receptor beta (THRB) signaling playing a pivotal role. This study probed the potential interaction between THRB action and another critical regulator of liver energy metabolism, the circadian clock. Liver transcriptome analysis of THRB deficient (THRBKO) mice under normal chow conditions revealed a markedly modest impact of THRB deletion. Temporal transcriptome and lipidome profiling uncovered significant alterations in diurnal metabolic rhythms attributable to THRB deficiency pointing to a pro-steatotic state with elevated levels of cholesterol, tri- and diacylglycerides, and fatty acids. These findings were confirmed by THRB agonization in hepatocytes under steatosis-promoting conditions in vitro. |
| Institute: | University of Luebeck |
| Department: | Bioanalytic Core facility |
| Last Name: | Inderhees |
| First Name: | Julica |
| Address: | Ratzburger Allee 160, Luebeck, Schleswig-Holstein, 23562, Germany |
| Email: | julica.inderhees@uni-luebeck.de |
| Phone: | +4945131012805 |
| Contributors: | Leonardo Vinicius Monteiro de Assis, Julica Inderhees |
Summary of all studies in project PR001904
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST003055 | Lipidomics analysis of the liver of THRB deficient (THRBKO) mice under normal chow conditions | Mus musculus | University of Luebeck | MS | 2024-08-14 | 1 | 36 | Uploaded data (8.6G)* |
