Summary of project PR001908
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001908. The data can be accessed directly via it's Project DOI: 10.21228/M83720 This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR001908 |
| Project DOI: | doi: 10.21228/M83720 |
| Project Title: | Identification of Plasma Diagnostic Biomarkers for Psoriasis Vulgaris through HILIC-HRMS Profling |
| Project Summary: | Psoriasis is an immune-mediated and chronic inflammatory skin disease Previous research on exploring psoriasis biomarkers using metabolomics lacks a validation step. Moreover, short peptide information in these studies was not investigated. Here, we conducted a comprehensive HILIC-HRMS-based plasma metabolomics study on different population sets, including healthy controls, psoriasis, and urticaria patients. With the aim of identifying potential biomarkers specific to psoriasis, the study design included a discovery step, a validation step, and a further refinement step using urticaria samples. We identified 9 potential biomarkers specific to psoriasis, with 5 being structurally characterized. Two dipeptide biomarkers, γ-GluSer and ThrGly, along with a lysine glycation metabolite, Fruc-Lys, were found to be associated with psoriasis for the first time. Receiver operating characteristic curve analysis revealed all these 9 biomarkers with AUC values above 0.80. A biomarker panel comprising ThrGly and Fruc-Lys demonstrated high diagnostic accuracy (AUC=0.95) in distinguishing psoriasis patients from healthy controls. |
| Institute: | Guangzhou University of Chinese Medicine |
| Department: | The Second Affiliated Hospital |
| Last Name: | ZHANG |
| First Name: | pp |
| Address: | Taipa, Avenida da Universidade, Taipa, Macau, China, 853, Macau, 853, Macau |
| Email: | yb47620@um.edu.mo |
| Phone: | 85388222534 |
Summary of all studies in project PR001908
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST003062 | Identification of Plasma Metabolites and Peptides as Diagnostic Biomarkers for Psoriasis Vulgaris through HILIC-HRMS-Based Metabolomics | Homo sapiens | Guangzhou University of Chinese Medicine | MS | 2024-08-05 | 1 | 88 | Uploaded data (25.7G)* |
