Summary of project PR001918

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001918. The data can be accessed directly via it's Project DOI: 10.21228/M8ST6K This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

Project ID: PR001918
Project DOI:doi: 10.21228/M8ST6K
Project Title:Metabolomics of Mouse Embryonic CSF Following Maternal Immune Activation
Project Summary:The embryonic cerebrospinal fluid (eCSF) is critical for the developing central nervous system (CNS), from neurogenesis to lifelong cognitive functions. Changes in eCSF composition due to inflammation can impact brain function. We recently identified an abnormal cytokine signature in eCSF following maternal immune activation (MIA), a mouse model of autism spectrum disorder (ASD). We hypothesized that MIA leads to other alterations in eCSF composition and employed untargeted metabolomics to profile changes in the eCSF metabolome in mice after inducing MIA with polyI:C. We report these data here as a resource, including a comprehensive MS1 and MS2 reference dataset, and present additional datasets comparing two mouse strains (CD-1 and C57Bl/6) and two developmental time points (E12.5 and E14.5). Targeted metabolomics further validated changes in eCSF upon MIA. We show a significant elevation of glucocorticoids and kynurenine pathway related metabolites. Both pathways are relevant for suppressing inflammation or could be informative as disease biomarkers. Our resource should inform future mechanistic studies regarding the etiology of MIA neuropathology and roles and contributions of eCSF metabolites to brain development.
Institute:Boston Childrens Hospital
Last Name:Petrova
First Name:Boryana
Address:300 Longwood Av, Boston, MA, 2115, USA
Email:boryana.petrova@childrens.harvard.edu
Phone:6173557433

Summary of all studies in project PR001918

Study IDStudy TitleSpeciesInstituteAnalysis
(* : Contains Untargted data)
Release
Date
VersionSamplesDownload
(* : Contains raw data)
ST003079 Metabolome changes in embryonic CSF (Part 1) Mus musculus Boston Children's Hospital, Harvard Medical School MS 2024-07-29 1 48 Uploaded data (6.3G)*
ST003080 Metabolome changes in embryonic CSF (Part 2) Mus musculus Boston Children's Hospital, Harvard Medical School MS 2024-07-29 1 27 Uploaded data (3.6G)*
ST003081 Metabolome changes in embryonic CSF (Part 3) Mus musculus Boston Children's Hospital, Harvard Medical School MS 2024-07-29 1 22 Uploaded data (2.6G)*
ST003082 Metabolome changes in embryonic CSF (Part 4) Mus musculus Boston Children's Hospital, Harvard Medical School MS 2024-07-29 1 48 Uploaded data (5.9G)*
ST003083 Metabolome changes in embryonic CSF (Part 5) Mus musculus Boston Children's Hospital, Harvard Medical School MS 2024-03-01 1 40 Uploaded data (3.3G)*
ST003084 Metabolome changes in embryonic CSF (Part 6) Mus musculus Boston Children's Hospital, Harvard Medical School MS* 2024-07-29 1 10 Uploaded data (1.2G)*
ST003085 Metabolome changes in embryonic CSF (Part 7) Mus musculus Boston Children's Hospital, Harvard Medical School MS 2024-07-29 1 11 Uploaded data (1.5G)*
ST003086 Metabolome changes in embryonic CSF (Part 8) Mus musculus Boston Children's Hospital, Harvard Medical School MS 2024-07-29 1 14 Uploaded data (2.1G)*
ST003087 Metabolome changes in embryonic CSF (Part 9) Mus musculus Boston Children's Hospital, Harvard Medical School MS 2024-07-29 1 9 Uploaded data (781.2M)*
ST003088 Metabolome changes in embryonic CSF (Part 10) Mus musculus Boston Children's Hospital, Harvard Medical School MS 2024-07-29 1 41 Uploaded data (5.5G)*
ST003089 Metabolome changes in embryonic CSF (Part 11) Mus musculus Boston Children's Hospital, Harvard Medical School MS 2024-07-29 1 10 Uploaded data (1.1G)*
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