Summary of project PR001920
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001920. The data can be accessed directly via it's Project DOI: 10.21228/M8JB09 This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR001920 |
| Project DOI: | doi: 10.21228/M8JB09 |
| Project Title: | T cell Immune Escape in Blast Crisis Transformation of Chronic Myeloid Leukemia |
| Project Type: | Untargeted metabolomics |
| Project Summary: | We report that leukemia secreted cytokines reduce miR-142 levels in T cells, causing T cell loss and exhaustion and therefore promoting CML BC transformation. Our homemade synthetic miR-142 increased T cell antileukemic activity and significantly prolonged the survival of CML BC murine and PDX models. |
| Institute: | Translational Genomics Research Institute |
| Department: | Integrated Mass Spectrometry Shared Resources |
| Last Name: | Pirrotte |
| First Name: | Patrick |
| Address: | 445 N 5th St Phoenix, AZ 85004 |
| Email: | ppirrotte@tgen.org |
| Phone: | 6023438400 |
| Contributors: | Bin Zhang, Khyatiben V. Pathak, Brooke Lovell, Nate Hansen, Patrick Pirrote, Le Xuan Truong Nguyen, Guido Marcucci, |
Summary of all studies in project PR001920
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST003091 | T cell Immune Escape in Blast Crisis Transformation of Chronic Myeloid Leukemia | Mus musculus | Translational Genomics Research Institute | MS* | 2024-03-01 | 1 | 224 | Uploaded data (18.3G)* |
