Summary of project PR001925

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001925. The data can be accessed directly via it's Project DOI: 10.21228/M8WM7T This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

Project ID: PR001925
Project DOI:doi: 10.21228/M8WM7T
Project Title:Cellular adaptation to cancer therapy along a resistance continuum
Project Summary:Recent research has shed light on the role of non-genetic plasticity in transient drug tolerance and the acquisition of stable resistance. However, the dynamics of cell state transitions occurring in the adaptation to cancer therapies remain elusive and require a systems-level longitudinal framework. Here we demonstrate that resistance develops through trajectories of cell state transitions accompanied by a progressive increase in cell fitness, which we denote the ‘resistance continuum’. This cellular adaptation involves a step-wise assembly of gene expression programs and epigenetically reinforced cell states underpinned by phenotypic plasticity stress adaptation and metabolic reprogramming. Through systematic genetic perturbations, we identify an acquisition of progressive metabolic dependencies, exposing a spectrum of vulnerabilities that can be potentially exploited therapeutically. The concept of the resistance continuum highlights the dynamic nature of cellular adaptation and calls for complementary therapies directed at the mechanisms underlying adaptive cell state transitions.
Institute:NYU Langone Health
Last Name:Starvaggi Franca
First Name:Gustavo
Address:430 E 29th Street
Email:Gustavo.StarvaggiFranca@nyulangone.org
Phone:646-501-4603
Funding Source:NIH grants: P50 CA225450

Summary of all studies in project PR001925

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ST003102 Cellular adaptation to cancer therapy along a resistance continuum Homo sapiens NYU Langone Health MS 2024-04-02 1 12 Uploaded data (303.6M)*
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