Summary of project PR001932
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001932. The data can be accessed directly via it's Project DOI: 10.21228/M80B0B This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR001932 |
| Project DOI: | doi: 10.21228/M80B0B |
| Project Title: | Untargeted Metabolomics Reveals Signatures of a Healthy Lifestyle |
| Project Type: | C18 Reversed-Phase Broad Spectrum Metabolomics |
| Project Summary: | This cross-sectional study investigated differences in the plasma metabolome in two groups of adults that were of similar age but varied markedly in body composition and dietary and physical activity patterns. Study participants included 52 adults in the lifestyle group (LIFE) (28 males, 24 females) and 52 in the control group (CON) (27 males, 25 females). The results using an extensive untargeted UPLC-HRMS analysis with 10,535 metabolite peaks identified 83 metabolites and 16 metabolic pathways that differentiated LIFE and CON groups. A novel metabolite signature of positive lifestyle habits emerged from this analysis highlighted by lower plasma levels of numerous bile acids, an amino acid profile characterized by higher histidine and lower glutamic acid, glutamine, β-alanine, phenylalanine, tyrosine, and proline, an elevated vitamin D status, higher levels of beneficial fatty acids and gut microbiome catabolism metabolites from plant substrates, and reduced levels of N-glycan degradation metabolites and environmental contaminants. This study established that the plasma metabolome is strongly associated with body composition and lifestyle habits. The robust lifestyle metabolite signature identified in this study is consistent with an improved life expectancy and a reduced risk for chronic disease. |
| Institute: | Metabolomics and Exposome Laboratory at UNC Nutrition Research Institute |
| Department: | Untargeted Analysis |
| Laboratory: | Sumner Lab |
| Last Name: | Rushing |
| First Name: | Blake |
| Address: | Nutrition Research Institute , University of North Carolina at Chapel Hill, 500 Laureate Way Kannapolis, NC 28081 |
| Email: | blake_rushing@unc.edu |
| Phone: | (704) 250-5000 |
Summary of all studies in project PR001932
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST003110 | Influence of Lifestyle Factors on Epigenetic and Proteomic Biomarkers: A Cross-Sectional Comparison | Homo sapiens | Appalachian State University | MS* | 2025-02-28 | 1 | 136 | Uploaded data (14.3G)* |
