Summary of project PR001943
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001943. The data can be accessed directly via it's Project DOI: 10.21228/M8K43P This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR001943 |
| Project DOI: | doi: 10.21228/M8K43P |
| Project Title: | Pulmonary maternal immune activation does not extend through the placenta but leads to fetal metabolic adaptation |
| Project Summary: | Maternal immune system activation (MIA) during pregnancy can disrupt the fetal environment, causing postnatal susceptibility to disorders. How the placenta and the fetus respond to acute MIA over time is unknown. Here, we characterized the response to acute maternal pulmonary inflammation across time in maternal and fetal organs using multi-omics. Unlike maternal organs which mounted strong innate immune responses, the placenta upregulated tissue-integrity genes, likely to prevent fetal exposure to infections, and downregulated growth-associated genes. Subsequently, the placenta upregulated biosynthesis and endoplasmic reticulum stress genes in order to return to homeostasis. These responses likely protected the fetus, since we observed no immune response in fetal liver. Instead, likely due to nutrient depletion, the fetal liver displayed metabolic adaptations, including increases in lipids containing docosahexaenoic acid, crucial for fetal brain development. Our study shows, for the first time, the integrated temporal response to pulmonary MIA across maternal and fetal organs. The study contains data from three different sources: Maternal liver samples, Fetal liver and Maternal blood. |
| Institute: | University of Copenhagen |
| Department: | Department of Biology |
| Laboratory: | Section for Computational and RNA Biology |
| Last Name: | Sandelin |
| First Name: | Albin |
| Address: | Copenhagen University Ole Maaloes Vej 5, DK2200, Copenhagen N, Denmark |
| Email: | albin@binf.ku.dk |
| Phone: | +45 224 56668 |
Summary of all studies in project PR001943
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST003125 | Pulmonary maternal immune activation does not extend through the placenta but leads to fetal metabolic adaptation - Fetal liver | Mus musculus | University of Copenhagen | MS | 2024-04-02 | 1 | 107 | Uploaded data (29.6G)* |
| ST003129 | Pulmonary maternal immune activation does not extend through the placenta but leads to fetal metabolic adaptation - Maternal liver | Mus musculus | University of Copenhagen | MS | 2024-04-02 | 1 | 72 | Uploaded data (16.8G)* |
| ST003130 | Pulmonary maternal immune activation does not extend through the placenta but leads to fetal metabolic adaptation - Maternal blood | Mus musculus | University of Copenhagen | MS | 2024-04-02 | 1 | 65 | Uploaded data (17.1G)* |
