Summary of project PR001948
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001948. The data can be accessed directly via it's Project DOI: 10.21228/M8XF0R This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR001948 |
| Project DOI: | doi: 10.21228/M8XF0R |
| Project Title: | Metabolomic study of T effector and T regulatory cells in severe allergic patients |
| Project Type: | MS untargeted analysis combining lipidomics and metabolomics. |
| Project Summary: | Metabolism has a profound impact on T cell fate and function. Uncovering the metabolome of circulating human CD4+ T effector memory (Teff) and T regulatory (Treg) cells would enable better understanding of Th2-driven diseases, such as allergy or asthma. Here, we demonstrated that in healthy humans, energy metabolism and functions of memory CD4+ Teff cells mainly relied on amino acids, whereas Treg cells predominantly used fatty acids. Arginine and phenylalanine increased T cell receptorinduced glycolysis and oxidative phosphorylation in total and memory CD4+ T cells, but high levels of phenylalanine limited CD4+ T cell proliferation via disrupting mitochondrial respiration and activation of L-phenylalanine oxidase, IL4I1. Accordingly, lowest levels of phenylalanine were linked with the pathogenic Th2a cells, and impaired Treg cells in patients with the most severe forms of allergies. It all suggests that phenylalanine is a metabolic checkpoint of pathogenic Th2 cells development. |
| Institute: | Universidad CEU San Pablo |
| Department: | Química y Bioquímica |
| Last Name: | Villaseñor |
| First Name: | Alma |
| Address: | Urbanización Montepríncipe, n/s, Boadilla del Monte, Madrid, 28003, Spain |
| Email: | alma.villasenor@ceu.es |
| Phone: | 913724750 |
Summary of all studies in project PR001948
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST003135 | Metabolomic study of T effector and T regulatory cells in severe allergic patients | Homo sapiens | Universidad CEU San Pablo | MS* | 2024-08-22 | 1 | 136 | Uploaded data (58.6G)* |
