Summary of project PR001959
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001959. The data can be accessed directly via it's Project DOI: 10.21228/M8H72Q This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR001959 |
| Project DOI: | doi: 10.21228/M8H72Q |
| Project Title: | YEATS4 Links Histone Crotonylation to Fatty-acid Uptake/Metabolism and Breast Cancer Stemness |
| Project Summary: | The integration between epigenetic regulation and metabolism is critical to maintaining cellular homeostasis. As an epigenetic mark mainly linked to gene activation, histone crotonylation (Kcr) uses the donor of crotonyl-CoA, a metabolite generated primarily from fatty acid oxidation. Whether there is an intrinsic crosstalk between histone Kcr and fatty acid metabolism remains to be explored. We report here that the YEATS family protein YEATS4 is a reader of histone Kcr preferentially towards H3K14cr. YEATS4 is amplified and overexpressed in breast cancer cells, mainly in the ER+ subtype. Integrative epigenomic and transcriptomic analyses reveal extensively overlapped chromatin distribution of YEATS4 with H3K14cr, leading to activation of multiple genes involved in fatty acid trafficking and metabolism, such as CD36, CPT1/2, and ACOX1. Depletion of YEATS4 in breast cancer cells led to compromised fatty acid uptake and β-oxidation. Interestingly, YEATS4 is upregulated in ALDH+ breast cancer stem cells, leading to boosted fatty acid metabolism, enhanced self-renewal, and accelerated tumor growth. Clinical pathological evidence indicates that elevated YEATS4 expression is correlated with a poor prognosis and worse overall survival in ER+ breast cancer patients. Together, our study uncovers a feedforward epigenetic-metabolic loop implicated in breast carcinogenesis, supporting the pursuit of YEATS4 as a potential therapeutic target for breast cancer intervention. |
| Institute: | Peking University |
| Last Name: | Peng |
| First Name: | Zijun |
| Address: | Xueyuan Road No.38, Beijing, Bejing, 100191, China |
| Email: | zj_peng@126.com |
| Phone: | +8617317790671 |
Summary of all studies in project PR001959
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST003153 | Untargeted metabolomic profile in control and YEATS4 knockdown MCF-7 cells | Homo sapiens | Peking University | MS* | 2025-09-15 | 1 | 15 | Uploaded data (1.6G)* |
