Summary of project PR001962
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001962. The data can be accessed directly via it's Project DOI: 10.21228/M83X6D This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR001962 |
| Project DOI: | doi: 10.21228/M83X6D |
| Project Title: | Diet modulates the protective effects of dimethyl fumarate mediated by the immunometabolic neutrophil receptor HCA2 |
| Project Type: | Metabolomics |
| Project Summary: | Monomethyl fumarate (MMF) and its prodrug dimethyl fumarate (DMF) are currently the most widely used agents for the treatment of multiple sclerosis (MS). However, not all patients benefit from DMF. We hypothesized that the variable response of patients may be due to their diet. In support of this hypothesis, mice subjected to experimental autoimmune encephalomyelitis (EAE), a model of MS, did not benefit from DMF treatment when fed a lauric acid-rich (LA) diet, in contrast to normal chow (NC) or, more so, a high-fiber (HFb) diet. DMF lacked efficacy in the LA diet fed group despite similar resorption and preserved effects on plasma lipids. |
| Institute: | University of Luebeck |
| Department: | Bioanalytic Core Facility |
| Last Name: | Inderhees |
| First Name: | Julica |
| Address: | Ratzburger Allee 160, Luebeck, Schleswig-Holstein, 23562, Germany |
| Email: | julica.inderhees@uni-luebeck.de |
| Phone: | +4945131012805 |
| Contributors: | Joanna Kosinska, Julian Assmann, Julica Inderhees |
Summary of all studies in project PR001962
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST003156 | Diet modulates the protective effects of dimethyl fumarate mediated by the immunometabolic neutrophil receptor HCA2 - Metabolomics | Mus musculus | University of Luebeck | MS | 2025-03-31 | 1 | 57 | Uploaded data (6.3G)* |
| ST003157 | Diet modulates the protective effects of dimethyl fumarate mediated by the immunometabolic neutrophil receptor HCA2 - Lipidomics | Mus musculus | University of Luebeck | MS | 2025-03-31 | 1 | 56 | Uploaded data (15.8G)* |
