Summary of project PR001966
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001966. The data can be accessed directly via it's Project DOI: 10.21228/M8KX6R This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR001966 |
| Project DOI: | doi: 10.21228/M8KX6R |
| Project Title: | Diet-omics in the Study of Urban and Rural Crohn disease Evolution (SOURCE) cohort |
| Project Summary: | Crohn disease (CD) burden has increased with globalization/urbanization, and the rapid rise is attributed to environmental changes rather than genetic drift. The Study Of Urban and Rural CD Evolution (SOURCE, n=380) has considered diet-omics domains simultaneously to detect complex interactions and identify potential beneficial and pathogenic factors linked with rural-urban transition and CD. We characterize exposures, diet, ileal transcriptomics, metabolomics, and microbiome in newly diagnosed CD patients and controls in rural and urban China and Israel. We show that time spent by rural residents in urban environments is linked with changes in gut microbial composition and metabolomics, which mirror those seen in CD. Ileal transcriptomics highlights personal metabolic and immune gene expression modules, that are directly linked to potential protective dietary exposures (coffee, manganese, vitamin D), fecal metabolites, and the microbiome. Bacteria-associated metabolites are primarily linked with host immune modules, whereas diet-linked metabolites are associated with host epithelial metabolic functions. |
| Institute: | Sheba hospital |
| Last Name: | Braun |
| First Name: | Tzipi |
| Address: | Sheba hospital, Ramat Gan, Ramat Gan, 52621, Israel |
| Email: | zipik0@gmail.com |
| Phone: | 97235305000 |
Summary of all studies in project PR001966
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST003161 | Diet-omics in the Study of Urban and Rural Crohn disease Evolution (SOURCE) cohort | Homo sapiens | Sheba hospital | MS | 2024-04-16 | 1 | 37 | Uploaded data (7.6G)* |
