Summary of project PR001975
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001975. The data can be accessed directly via it's Project DOI: 10.21228/M8F723 This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR001975 |
| Project DOI: | doi: 10.21228/M8F723 |
| Project Title: | Chronic manganese exposure disrupts glutamatergic signaling and alters behavior in APP/PSEN1 mice. |
| Project Type: | Untargeted Metabolomics analysis |
| Project Summary: | Pathological changes in Alzheimer’s disease (AD) begin decades before cognitive symptoms appear. Chronic exposure to environmental neurotoxins like manganese (Mn) from sources such as air pollution and water can impact disease development across decades. Mn toxicity can lead to motor and neuropsychiatric symptoms resembling Parkinson's disease, attributed to its accumulation in globus pallidus. In contrast, the impact of chronic lower-level exposures on normal and neuropathological brain function is unknown. We tested whether 10 months of a high Mn diet (2400 ppm) could alter aspects of glutamate signaling in APP/PSEN1 mice to further exacerbate cognitive impairments compared to control fed animals (70 ppm). This study supports the potential role for chronic environmental exposures in the development of Alzheimer’s disease associated neuropathology. |
| Institute: | Vanderbilt University |
| Department: | Chemistry |
| Laboratory: | Center for Innovative Technology |
| Last Name: | CODREANU |
| First Name: | SIMONA |
| Address: | 1234 STEVENSON CENTER LANE |
| Email: | SIMONA.CODREANU@VANDERBILT.EDU |
| Phone: | 6158758422 |
Summary of all studies in project PR001975
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST003176 | Chronic manganese exposure disrupts glutamatergic signaling and alters behavior in APP/PSEN1 mice. | Mus musculus | Vanderbilt University | MS* | 2024-10-18 | 1 | 105 | Uploaded data (40.1G)* |
