Summary of project PR001977
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001977. The data can be accessed directly via it's Project DOI: 10.21228/M85Q8Q This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR001977 |
| Project DOI: | doi: 10.21228/M85Q8Q |
| Project Title: | Deep phenotyping of Post-infectious Myalgic Encephalomyelitis/Chronic Fatigue Syndrome |
| Project Summary: | Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a disabling disorder that may occur following an infection, yet the clinical phenotype is poorly defined, the pathophysiology is unknown, and no disease-modifying treatments are available. We used rigorous criteria to recruit a cohort of post-infectious ME/CFS (PI-ME/CFS) volunteers (n=17) with matched healthy controls (n=21) to conduct deep clinical and biological phenotyping using an extensive battery of tests. Among the many physical and cognitive complaints, one defining feature of PI-ME/CFS was an alteration of effort preference, rather than physical or central fatigue, due to dysfunction of integrative brain regions potentially associated with central catechol pathway dysregulation, with consequences on autonomic functioning and physical deconditioning. Immune profiling suggested chronic antigenic stimulation with increase in naïve and decrease in switched memory B-cells. Alterations in gene expression profiles of peripheral blood mononuclear cells and metabolic pathways were consistent with cellular phenotypic studies and demonstrated differences according to sex. Together these clinical abnormalities and biomarker differences provide unique insight into the underlying pathophysiology of PI-ME/CFS, which may guide future intervention. |
| Institute: | National Institutes of Health |
| Department: | NINDS |
| Laboratory: | National Institute of Neurological Disorders and Stroke |
| Last Name: | Nath |
| First Name: | Avindra |
| Address: | 10 Center Drive, Bethesda, MD 20892 |
| Email: | Avindra.nath@nih.gov |
| Phone: | 301.496.1561 |
Summary of all studies in project PR001977
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST003178 | Post-Infectious MECFS at the NIH | Homo sapiens | National Institutes of Health | MS | 2024-05-14 | 1 | 38 | Uploaded data (1.1M) |
