Summary of project PR001982
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001982. The data can be accessed directly via it's Project DOI: 10.21228/M8J14Q This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR001982 |
| Project DOI: | doi: 10.21228/M8J14Q |
| Project Title: | Campylobacter infection of young children in Colombia and its impact on the gastrointestinal metabolome |
| Project Type: | MS quantitative analysis |
| Project Summary: | Campylobacter infections are a leading cause of bacterial-derived gastroenteritis worldwide with particularly profound impacts on pediatric patients in low-and-middle income countries. It remains unclear how Campylobacter impacts these hosts, though it is becoming increasingly evident that it is a multifactorial process that depends on the host immune response, the gastrointestinal microbiota, various bacterial factors, and host nutritional status. Since these factors likely vary between adult and pediatric patients in different regions of the world, it is important that studies define these attributes in well characterized clinical cohorts in diverse settings. In this study, we analyzed the metabolomic profiles of asymptomatic and symptomatic pediatric patients in Colombia that were either infected or uninfected with Campylobacter during a case-controlled study on acute diarrheal disease. Using computational models, we identified fecal metabolites that were associated with Campylobacter infection and found that glucose-6-phosphate and homovanillic acid were the strongest predictors of infection in these pediatric patients, which suggest that colonocyte metabolism are impacted during infection. |
| Institute: | University of Tennessee |
| Department: | Microbiology |
| Laboratory: | Johnson |
| Last Name: | Johnson |
| First Name: | Jeremiah |
| Address: | 1311 Cumberland Avenue, Knoxville, TN, 37996, USA |
| Email: | jjohn358@utk.edu |
| Phone: | 8659746229 |
Summary of all studies in project PR001982
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST003183 | Campylobacter infection of young children in Colombia and its impact on the gastrointestinal metabolome | Homo sapiens | University of Tennessee | MS | 2024-09-19 | 1 | 39 | Uploaded data (3.7G)* |
