Summary of project PR001984
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001984. The data can be accessed directly via it's Project DOI: 10.21228/M88J0W This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR001984 |
| Project DOI: | doi: 10.21228/M88J0W |
| Project Title: | A metabolic atlas of mouse aging |
| Project Summary: | Humans are living longer, but this is accompanied by an increased incidence of age-related chronic diseases. Many of these diseases are influenced by age-associated metabolic dysregulation, but how metabolism changes in multiple organs during aging in males and females is not known. Answering this could reveal new mechanisms of aging and age-targeted therapeutics. In this study, we describe how metabolism changes in 12 organs in male and female mice at 5 different ages. Organs show distinct patterns of metabolic aging that are affected by sex differently. Hydroxyproline shows the most consistent change across the dataset, decreasing with age in 11 out of 12 organs investigated. We also developed a metabolic aging clock that predicts biological age and identified alpha-ketoglutarate, previously shown to extend lifespan in mice, as a key predictor of age. Our results reveal fundamental insights into the aging process and identify new therapeutic targets to maintain organ health. |
| Institute: | University of Southern California |
| Department: | Keck School of Medicine |
| Laboratory: | Mullen Lab |
| Last Name: | Pilley |
| First Name: | Steven |
| Address: | 1501 San Pablo St., Los Angeles, CA, 90033, USA |
| Email: | pilley@usc.edu |
| Phone: | +13234427555 |
| Funding Source: | Impetus Grants 014746-00001 |
Summary of all studies in project PR001984
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST003188 | A metabolic atlas of mouse aging | Mus musculus | University of Southern California | MS | 2025-11-18 | 1 | 903 | Uploaded data (3.2G)* |
| ST004278 | Investigating the immediate metabolic effects of acute alpha-ketoglutarate supplementation in mice | Mus musculus | University of Southern California | MS | 2025-11-19 | 1 | 136 | Uploaded data (464.9M)* |
| ST004279 | Metabolic aging in human pancreas | Homo sapiens | University of Southern California | MS | 2025-11-19 | 1 | 41 | Uploaded data (152.8M)* |
