Summary of project PR001992
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001992. The data can be accessed directly via it's Project DOI: 10.21228/M87J0K This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR001992 |
| Project DOI: | doi: 10.21228/M87J0K |
| Project Title: | Unveiling cellular changes in leukaemia cell line HL-60 after cannabidiol treatment through lipidomics |
| Project Summary: | The present study was aimed at revealing the metabolic changes that occurred in the cellular lipid pattern of acute and chronic myeloid leukaemia cells following treatment with cannabidiol (CBD). CBD is a non-psychoactive compound present in Cannabis sativa L., which has shown an antiproliferative action in these type of cancer cells, to determine significant alterations of the cell metabolism attributable to the induction of apoptosis, previously observed from in vitro studies. Control and treated cells of acute myeloid leukaemia (HL-60) were studied through an untargeted lipidomics approach. Treatment was carried out with CBD at a concentration of 10 μM for 48 h. After the extraction of the lipid content from cell lysates, the samples were analysed by UHPLC-QTOF-MS/MS both in the positive and the negative ionization modes. |
| Institute: | Universidad CEU San Pablo |
| Laboratory: | CEMBIO |
| Last Name: | Garcia Fernández |
| First Name: | Antonia |
| Address: | Urb. Montepríncipe., Alcorcón, Madrid, 28925, Spain |
| Email: | antogar@ceu.es |
| Phone: | (+34) 91 372 47 69 |
Summary of all studies in project PR001992
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST003196 | Unveiling cellular changes in leukaemia cell line HL-60 after cannabidiol treatment through lipidomics | Homo sapiens | Universidad CEU San Pablo | MS* | 2024-09-17 | 1 | 10 | Uploaded data (3.4G)* |
