Summary of project PR002004
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR002004. The data can be accessed directly via it's Project DOI: 10.21228/M8K819 This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR002004 |
| Project DOI: | doi: 10.21228/M8K819 |
| Project Title: | The central role of creatine and polyamines in fetal growth restriction |
| Project Summary: | Placental insufficiency is often associated with fetal growth restriction (FGR), a condition associated with both short- and long-term complications for newborns. In this study, we performed a comprehensive transcriptomic and metabolomic characterization of the placenta of newborns born small for gestational age (SGA) and appropriate for gestational age (AGA). Transcriptome and metabolome data obtained from villous tissue biopsies and verified in 3D trophoblast organoids revealed that the defective placentas associated with FGR are characterized by metabolic reprogramming consisting of adaptation to hypoxia and alteration of arginine metabolism, particularly at the level of synthesis of polyamines and creatine phosphate. Arginine was utilized in defective SGA placentas to synthesize phosphocreatine, an energy-rich compound that is critical for ATP production and represents a positive metabolic adaptation that supports trophoblast fitness. In addition, SGA placentas were characterized by a deficit in polyamines due to overexpression of SAT1. SAT1 catalyzes the acetylation of spermine and spermidine and promotes their excretion from the trophoblast, resulting in a deficit of polyamines that cannot be compensated by arginine or polyamine supplementation unless SAT1 expression is disrupted. In conclusion, our study improves the understanding of metabolic adaptations associated with placental dysfunction and provides valuable insights for future therapeutic interventions. |
| Institute: | University of Udine |
| Department: | Medicine |
| Laboratory: | Biochemistry |
| Last Name: | Di Giorgio |
| First Name: | Eros |
| Address: | piazzale Kolbe 4, Udine, Italy, 33100, Italy |
| Email: | eros.digiorgio@uniud.it |
| Phone: | +39/0432494338 |
| Funding Source: | PRIN PNRR |
Summary of all studies in project PR002004
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST003213 | The central role of creatine and polyamines in fetal growth restriction | Homo sapiens | University of Udine | MS | 2025-04-21 | 1 | 6 | Uploaded data (14.7M)* |
