Summary of project PR002005
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR002005. The data can be accessed directly via it's Project DOI: 10.21228/M8FJ9V This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR002005 |
| Project DOI: | doi: 10.21228/M8FJ9V |
| Project Title: | Protein restriction slows the development and progression of Alzheimer's disease in mice |
| Project Type: | MS targeted lipidomics |
| Project Summary: | Dietary protein is a critical regulator of metabolic health and aging. Low protein diets are associated with healthy aging in humans, and many independent groups of researchers have shown that dietary protein restriction (PR) extends the lifespan and healthspan of mice. Here, we examined the effect of PR on metabolic health and the development and progression of Alzheimer’s disease (AD) in the 3xTg mouse model of AD. We found that PR has metabolic benefits for 3xTg mice and non-transgenic controls of both sexes, promoting leanness and glycemic control in 3xTg mice and rescuing the glucose intolerance of 3xTg females. We found that PR induces sex-specific alterations in circulating metabolites and in the brain lipidome, downregulating sphingolipid subclasses including ceramides, glucosylceramides, and sphingomyelins in 3xTg females. Consumption of a PR diet starting at 6 months of age reduced AD pathology in conjunction with reduced mTORC1 activity, increased autophagy, and had cognitive benefits for 3xTg mice. Finally, PR improved the survival of 3xTg mice. Our results demonstrate that PR slows the progression of AD at molecular and pathological levels, preserves cognition in this mouse model of AD, and suggests that PR or pharmaceutical interventions that mimic the effects of this diet may hold promise as a treatment for AD. |
| Institute: | University of Wisconsin-Madison |
| Last Name: | Simcox |
| First Name: | Judith |
| Address: | 433 Babcock Dr, Madison, WI, 53706, USA |
| Email: | jsimcox@wisc.edu |
| Phone: | - |
Summary of all studies in project PR002005
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST003215 | Protein restriction slows the development and progression of Alzheimer's disease in mice | Mus musculus | University of Wisconsin-Madison | MS | 2024-06-12 | 1 | 40 | Uploaded data (20.3M)* |
