Summary of project PR002006
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR002006. The data can be accessed directly via it's Project DOI: 10.21228/M89R6J This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR002006 |
| Project DOI: | doi: 10.21228/M89R6J |
| Project Title: | Balancing brain metabolic states during sickness and recovery sleep |
| Project Summary: | Sickness sleep and rebound following sleep deprivation share humoral signals including the rise of cytokines, in particular interleukins. Nevertheless, they represent unique physiological states with unique brain firing patterns and involvement of specific circuitry. Here we performed untargeted metabolomics of mouse cortex and hippocampus to uncover acute changes with sickness and rebound sleep as compared to normal daily sleep. We found that the three states are biochemically unique with larger differences in the cortex than in the hippocampus. Both sickness and rebound sleep shared an increase in tryptophan, with the highest levels during sickness. Surprisingly these two sleep states showed stark differences in terms of the energetic signature, with sickness impinging on glycolysis intermediates whilst rebound increased the triphosphorylated form of nucleotides. These findings indicate that rebound following sleep deprivation stimulates an energy rich state in the brain that is devoid during sickness sleep in line with the energy conservation hypothesis of sickness behavior. |
| Institute: | University of Pennsylvania |
| Last Name: | Sehgal |
| First Name: | Amita |
| Address: | Perelman School of Medicine, University of Pennsylvania, 10-136 Smilow Research Center, 3400 Civic Center Blvd, Bldg 421, Philadelphia, PA 19104, USA |
| Email: | amita@pennmedicine.upenn.edu |
| Phone: | 215-898-2799 |
Summary of all studies in project PR002006
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST003216 | Balancing brain metabolic states during sickness and recovery sleep | Mus musculus | University of Pennsylvania | MS | 2025-05-21 | 1 | 28 | Uploaded data (4.6G)* |
