Summary of project PR002010
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR002010. The data can be accessed directly via it's Project DOI: 10.21228/M8SR78 This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR002010 |
| Project DOI: | doi: 10.21228/M8SR78 |
| Project Title: | The Ataxia-Telangiectasia Mutated Kinase Inhibitor AZD0156 is a Potent Inhibitor of Plasmodium Phosphatidylinositol 4-Kinase and is an Attractive Candidate for Repositioning Against Malaria |
| Project Summary: | Here we interrogated the in vitro metabolic effects of AZD0156 using ultra-high performance liquid chromatography mass-spectrometry (UHPLC-MS). The resulting metabolic fingerprints provide information on the parasite biochemical pathways affected by pharmacologic intervention. We interrogate the metabolic effects on the 3D7 parasite strain. The metabolic effects were compared to their parent strain. The metabolic fingerprints provided show that certain biochemical pathways are affected by the drug inhibitory effect. |
| Institute: | Pennsylvania State University |
| Last Name: | Llinas |
| First Name: | Manuel |
| Address: | W126 Millenium Science Complex, University Park, PA 16802 |
| Email: | manuel@psu.edu |
| Phone: | 814-867-3527 |
Summary of all studies in project PR002010
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST003224 | The Ataxia-Telangiectasia Mutated Kinase Inhibitor AZD0156 is a Potent Inhibitor of Plasmodium Phosphatidylinositol 4-Kinase and is an Attractive Candidate for Repositioning Against Malaria | Plasmodium falciparum | Pennsylvania State University | MS | 2025-05-07 | 1 | 15 | Uploaded data (5.5G)* |
