Summary of project PR002019
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR002019. The data can be accessed directly via it's Project DOI: 10.21228/M8N23M This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR002019 |
| Project DOI: | doi: 10.21228/M8N23M |
| Project Title: | 4-diet multi-organ and multi-omic crosstalk |
| Project Type: | Targeted MS quantitative analysis |
| Project Summary: | Presently, dietary patterns have undergone significant shifts, and understanding the intricate interplay between diet, particularly high fat and high sucrose diets, the gut microbiome, and cardiometabolic health has become paramount. These dietary patterns have been consistently associated with heightened cardiometabolic risk factors including obesity, insulin resistance, dyslipidemia, and hypertension. High-fat diets, in particular, contribute to increased adiposity and ectopic fat deposition, exacerbating systemic inflammation and oxidative stress, thereby promoting the development of metabolic dysfunction. Similarly, high sucrose diets have been implicated in the dysregulation of glucose homeostasis, leading to insulin resistance and hyperglycemia, key hallmarks of cardiometabolic diseases such as type 2 diabetes mellitus. Amidst this, the exploration of multi-omic profiles alongside the gut microbial landscape has emerged as a pivotal avenue for unraveling the complexities of cardiometabolic health dynamics affected by the effects of high-fat and high-sucrose diets. The approach of using a multi-omic comparison between organs offers a comprehensive lens through which the intricate molecular signatures underlying the impact of dietary compositions, particularly high fat and high sucrose, on metabolic health, can be examined. |
| Institute: | University of Sydney |
| Department: | School of Medical Sciences |
| Laboratory: | Cardiometabolic Disease |
| Last Name: | Liu |
| First Name: | Renping |
| Address: | The Hub, Charles Perkins Centre, D17, The University of Sydney, NSW, 2006 |
| Email: | renping.liu@sydney.edu.au |
| Phone: | +61432953638 |
Summary of all studies in project PR002019
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST003252 | Metabolomics studies on mouse cardiac samples on a Western diet | Mus musculus | University of Sydney | MS | 2024-08-26 | 1 | 35 | Uploaded data (7.2M)* |
| ST003253 | Metabolomics studies on mouse liver samples on a Western diet | Mus musculus | University of Sydney | MS | 2024-08-26 | 1 | 31 | Uploaded data (9.5M)* |
