Summary of project PR002033
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR002033. The data can be accessed directly via it's Project DOI: 10.21228/M8TN7J This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR002033 |
| Project DOI: | doi: 10.21228/M8TN7J |
| Project Title: | Phosphate availability conditions caspofungin tolerance, capsule attachment and titan cell formation in Cryptococcus neoformans |
| Project Summary: | There is a pressing need for new antifungal drugs to treat invasive fungal diseases. Unfortunately, the echinocandin drugs that are fungicidal against other important fungal pathogens are ineffective against Cryptococcus neoformans, the causative agent of life-threatening meningoencephalitis in immunocompromised people. Contributing mechanisms for echinocandin tolerance are emerging with connections to calcineurin signaling, the cell wall, and membrane composition. In this context, we discovered that a defect in phosphate uptake impairs the tolerance of C. neoformans to the echinocandin caspofungin. |
| Institute: | Life Sciences Institute, The University of British Columbia |
| Last Name: | Alcazar Magana |
| First Name: | Armando |
| Address: | 2350 Health Sciences Mall |
| Email: | armando.alcazarmagana@ubc.ca |
| Phone: | 5416097172 |
Summary of all studies in project PR002033
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST003281 | Phosphate availability conditions caspofungin tolerance, capsule attachment and titan cell formation in Cryptococcus neoformans | Cryptococcus neoformans | University of British Columbia | MS | 2024-06-28 | 1 | 44 | Uploaded data (10.7G)* |
