Summary of project PR002045
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR002045. The data can be accessed directly via it's Project DOI: 10.21228/M88N7K This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR002045 |
| Project DOI: | doi: 10.21228/M88N7K |
| Project Title: | High Fat Feeding Alters Circulating Triglyceride Profile by Decreasing SCD Activity and Depleting omega-3 Fatty Acids |
| Project Summary: | The study was to examine, in control and high-fat-fed rats, the effects of acute feeding (a single meal) on circulating lipid profiles. Acute feeding is expected to impact circulating lipid profiles due to lipids in chylomicron derived from the diet, and the acute feeding response may be altered with a HFD to account for some of the chronic effects of a HFD. The study was to examine the effects of a high fat diet (HFD) on circulating TG profiles in rats and test the hypothesis that a HFD reduces TGs composed of long-chain PUFAs, as previously seen in rats maintained on a HNaLK diet. Thus, we performed lipidomics analysis on plasma samples collected both in the pre- and postprandial states in the control and HFD groups. Lipidomics analysis was combined with general metabolomics analysis, which provides measurements of saturated FFAs and other metabolic indicators such as glycerol (as lipolysis indicator) or 3-hydroxybutyrate (ketosis indicator), not measured in our LC-MS-based lipidomics assay. The results provided novel insights into the differential behaviors of individual TGs and identified specific changes (i.e., decreased stearoyl-CoA desaturase [SCD] activity and depletion of omega-3 FFAs) associated with short-term high-fat feeding. |
| Institute: | University of Southern California |
| Department: | Keck School of Medicine USC |
| Last Name: | Youn |
| First Name: | Jang-Hyun |
| Address: | CSC 214, 2250 Alcazar Street, Health Sciences Campus, Los Angeles CA 90033 |
| Email: | youn@usc.edu |
| Phone: | 5307528129 |
Summary of all studies in project PR002045
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST003293 | High Fat Feeding Alters Circulating Triglyceride Profile by Decreasing SCD Activity and Depleting omega-3 Fatty Acids | Rattus norvegicus | University of Southern California | MS | 2024-07-25 | 1 | 58 | Uploaded data (908.3M)* |
