Summary of project PR002052
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR002052. The data can be accessed directly via it's Project DOI: 10.21228/M8CG1H This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR002052 |
| Project DOI: | doi: 10.21228/M8CG1H |
| Project Title: | Untargeted Dialysate Metabolomics Identification and Detection of Novel Neurochemicals via Benzoyl Chloride Derivatization |
| Project Summary: | This study combines these strategies to obtain in-depth untargeted chemical identification of dialysate. We target the rat dorsal and ventral striatum, given its importance in motivation, movement, and reward processing and identify 489 compounds. Despite the depth of analysis, many well-known neurochemicals, such as all neurotransmitters, were not identified in the untargeted method. These compounds could be detected using BzCl derivation in a targeted method though. By tracking isotopic BzCl feature pair detection and filtering of MS/MS spectra by known benzoyl fragment ions, we found 872 unique features in dialysate suggesting many unknown compounds remain to be identified in dialysate. |
| Institute: | University of Michigan |
| Last Name: | Anderson |
| First Name: | Brady |
| Address: | 930 N. University Ann Arbor, MI 48109 |
| Email: | anderbra@umich.edu |
| Phone: | 6519256798 |
| Funding Source: | NIH (NINDD,NIEHS) |
| Publications: | to be updated later |
| Contributors: | Brady Anderson, Pavlo Popov, Amanda Cicali, Adana Nwamba, Charles R. Evans, Robert T. Kennedy |
Summary of all studies in project PR002052
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST003302 | Untargeted Dialysate Metabolomics Identification and Detection of Novel Neurochemicals via Benzoyl Chloride Derivatization | Rattus norvegicus | University of Michigan | MS | 2024-09-24 | 1 | 18 | Uploaded data (22.1G)* |
