Summary of project PR002053
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR002053. The data can be accessed directly via it's Project DOI: 10.21228/M87N78 This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR002053 |
| Project DOI: | doi: 10.21228/M87N78 |
| Project Title: | Metabolic Alterations in Aneurysmal Subarachnoid Hemorrhage |
| Project Summary: | Aneurysmal subarachnoid hemorrhage (aSAH) is a severe type of stroke that is associated with poor outcome. A subset of patients with aSAH will develop secondary complications, most notably delayed cerebral ischemia (DCI), which potentiates neurological injury. In this study, we investigate the relationship between cerebrospinal fluid (CSF) iron accumulation, brain metabolism, and neuronal injury in aSAH patients with or without DCI. We collected longitudinal CSF samples of patients immediately after hospitalization and 5-8 days after onset of ictus. CSF was analyzed with metabolomics to determine metabolic alterations associated with aSAH and DCI. Metabolomic profiling of the CSF samples uncovered significant dysregulation of metabolic pathways associated with energy generation and amino acid utilization, consistent with mitochondrial dysfunction. Using machine learning, we identified a set of metabolites that predicted ICU length of stay (LOS). aSAH alters the CSF metabolome involved in mitochondrial function and a subset of these metabolites are predictive of ICU stay. These results identify potential biomarkers for mitochondrial pathology and provide insight into alterations in brain iron metabolism triggered by aSAH. |
| Institute: | University of Akron |
| Department: | Chemistry |
| Last Name: | Pacheco |
| First Name: | Gardenia |
| Address: | 190 E. Buchtel Common, Akron, OH 44325 |
| Email: | gardenia.pacheco2@gmail.com |
| Phone: | 815-299-2731 |
Summary of all studies in project PR002053
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST003303 | Metabolic Alterations in Aneurysmal Subarachnoid Hemorrhage | Homo sapiens | University of Akron | MS* | 2024-07-29 | 1 | 41 | Uploaded data (2G)* |
