Summary of project PR002066
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR002066. The data can be accessed directly via it's Project DOI: 10.21228/M8JZ41 This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR002066 |
| Project DOI: | doi: 10.21228/M8JZ41 |
| Project Title: | Analysis of EBC metabolomics in non-small cell lung cancer patients and control individuals |
| Project Summary: | A total of 18 EBC differential metabolites (FDR < 0.05) were identified, which included phenylalanine and tryptophan, dipeptides related to BCAAs, unsaturated, oxidized and hydroxyl fatty acids, and other compounds. Among them, 8 differential metabolites had AUC > 0.8, exhibiting distinct levels in the NSCLC and control EBC samples. Two OPLS-DA models were established from the differential metabolites with FDR < 0.05 and FDR < 0.01, with a 5-metabolite panel and a 4-metabolite panel, respectively. The OPLS-DA model achieved 86.2% sensitivity, 83.3% specificity and 84.9% accuracy for the 5-metabolite panel, and 79.3% sensitivity, 83.3% specificity and 81.1% accuracy for the 4-metabolite panel. The EBC differential metabolites between the NSCLC and control groups showed a potential to distinguish NSCLC from controls, which may provide assistance for noninvasive diagnosis of lung cancer, once they are validated in large cohort studies. |
| Institute: | Ocean University of China |
| Last Name: | sha |
| First Name: | Wang |
| Address: | No. 5 Yushan Road, Qingdao, Shandong, China |
| Email: | wangsha@stu.ouc.edu.cn |
| Phone: | 18851091031 |
Summary of all studies in project PR002066
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST003322 | EBC metabolomics in non-small cell lung cancer patients and control individuals | Homo sapiens | Ocean University of China | MS* | 2024-08-01 | 1 | 108 | Uploaded data (10.6G)* |
