Summary of project PR002068
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR002068. The data can be accessed directly via it's Project DOI: 10.21228/M89F9K This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR002068 |
| Project DOI: | doi: 10.21228/M89F9K |
| Project Title: | Lipidome profiling in non-alcoholic steatohepatitis identifies phosphatidylserine synthase 1 as a regulator of hepatic lipoprotein metabolism |
| Project Summary: | This project aimed to investigate the regulation of the hepatic lipidome in mice with non-alcoholic steatohepatitis (NASH) and liver fibrosis, and assess the differences in the hepatic lipidome in mouse strains susceptible or resistant to NASH and metabolic comorbidities. For this purpose, eight mouse strains were fed either a chow control diet or a western-style diet enriched in lipid, carbohydrate and cholesterol for 30-32 weeks, followed by in-depth metabolic phenotyping, assessment of liver pathology and the hepatic lipidome by LC/MS. This study found that resistance to diet-induced NASH in BALB/c mice was associated with increased hepatic phosphatidylserine (PS) content. Subsequent studies focusing on overexpression of PS synthase 1 (PSS1) in the livers of mice with steatosis or NASH show that increasing hepatic PS is associated with improvements in steatosis and/or inflammation. |
| Institute: | University of Melbourne |
| Last Name: | Montgomery |
| First Name: | Magdalene |
| Address: | Corner Grattan Street Royal Parade, Melbourne, Victoria, 3010, Australia |
| Email: | magdalene.montgomery@unimelb.edu.au |
| Phone: | 0422059907 |
Summary of all studies in project PR002068
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST003326 | Lipidome profiling in non-alcoholic steatohepatitis identifies phosphatidylserine synthase 1 as a regulator of hepatic lipoprotein metabolism | Mus musculus | University of Melbourne | MS | 2024-10-21 | 1 | 290 | Uploaded data (68.3G)* |
