Summary of project PR002074
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR002074. The data can be accessed directly via it's Project DOI: 10.21228/M8HZ53 This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR002074 |
| Project DOI: | doi: 10.21228/M8HZ53 |
| Project Title: | Biological stress metabolomics in Duchenne muscular dystrophy rodent model |
| Project Type: | Biological Stress Discovery Targeted Metabolomics |
| Project Summary: | Our goal is to identify stress-relevant metabolomic alterations in dystrophin-deficient organisms following physiological stress exposure. Here we performed a targeted mass spectrometry-based plasma metabolomics screen through Metabolon that focused on biological stress pathways in healthy and dystrophin-deficient mdx mice exposed to mild scruff stress. One-third of the stress-relevant metabolites interrogated displayed significant elevation or depletion in mdx plasma after scruff stress and were restored to WT by skeletal muscle-specific dystrophin expression. The metabolic pathways of mdx mice altered by scruff stress are associated with regulation of the hypothalamic-pituitary-adrenal axis, locomotor tone, neurocognitive function, redox metabolism, cellular bioenergetics, and protein catabolism. Our data suggest that a mild stress triggers an exaggerated, multi-system metabolic response in mdx mice. |
| Institute: | University of Minnesota |
| Department: | Biochemistry, Molecular Biology, and Biophysics |
| Laboratory: | James Ervasti |
| Last Name: | Johnson |
| First Name: | Erynn |
| Address: | 420 Washington Ave SE |
| Email: | joh18358@umn.edu |
| Phone: | 4024054007 |
| Funding Source: | 5T32AR007612-21; 5T32AR007612-22; 5T32AG029796-13; 5T32AG029796-14; 5R01AR042423-27; 5R01AR049899-18 |
| Contributors: | Erynn E. Johnson; James M. Ervasti |
Summary of all studies in project PR002074
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST003335 | Biological stress metabolomics in Duchenne muscular dystrophy rodent model | Mus musculus | University of Minnesota | MS | 2024-08-09 | 1 | 48 | Uploaded data (2.9M) |
