Summary of project PR002076
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR002076. The data can be accessed directly via it's Project DOI: 10.21228/M88G1K This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR002076 |
| Project DOI: | doi: 10.21228/M88G1K |
| Project Title: | Characterization of Metabolic and Molecular Effects Following Dietary Exposure to the Plasticizer DINCH in vivo |
| Project Summary: | With the phthalate plasticizer di-(2-ethylhexyl) phthalate (DEHP) being restricted because of its harmful health impacts, it has been replaced by alternatives such as diisononylcyclohexane-1,2-dicarboxylate (DINCH). Although recent research suggests that the main metabolite of DINCH, monoisononylcyclohexane-1,2-dicarboxylic acid ester (MINCH), promotes adipocyte differentiation in vitro, in vivo studies have not shown changes in body weight, lipid metabolism, or adipogenic effects. However, these studies followed OECD guidelines, which are not specifically designed to detect potential metabolic disruptions in adipose tissue. Therefore, we conducted an in-depth in vivo study using the C57BL/6N mouse model to comprehensively evaluate the physiological and functional impacts of DINCH exposure on adipose tissue, including molecular-level effects. |
| Institute: | Helmholtz Centre for Environmental Research |
| Last Name: | Engelmann |
| First Name: | Beatrice |
| Address: | Permoserstr. 15, 04299 Leipzig |
| Email: | beatrice.engelmann@ufz.de |
| Phone: | 004934160251099 |
Summary of all studies in project PR002076
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST003339 | DINCH and MINCH reach adipose and liver tissues and levels are partially retained during recovery period | Mus musculus | Helmholtz Centre for Environmental Research | MS | 2024-08-12 | 1 | 427 | Uploaded data (25.4M)* |
