Summary of project PR002077
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR002077. The data can be accessed directly via it's Project DOI: 10.21228/M84R60 This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR002077 |
| Project DOI: | doi: 10.21228/M84R60 |
| Project Title: | Validation of ferroptosis in canine cancer cells to enable comparative oncology and translational medicine |
| Project Summary: | Ferroptosis is a cell death mechanism that has attracted significant attention as a potential basis for the development of new cancer therapies. Validation of ferroptosis biology in species commonly used in translation and pre-clinical development is a necessary foundation for enabling the advancement of such ferroptosis modulating drugs. Here, we demonstrate that canine cancer cells exhibit sensitivity to a wide range of ferroptosis-inducing perturbations in a manner indistinguishable from human cancer cells, and recapitulate characteristic patterns of ferroptotic response across tumor types seen in the human setting. We further performed lipidomic profiling of all canine cancer cell lines to enable the discovery of lipid biomarkers for ferroptosis sensitivity. The foundation provided herein establishes the dog as a relevant efficacy and toxicology model for ferroptosis and creates new opportunities to leverage the canine comparative oncology paradigm to accelerate the development of ferroptosis-inducing drugs for human cancer patients. |
| Institute: | Kojin Therapeutics, Inc. |
| Last Name: | Wawer |
| First Name: | Mathias |
| Address: | 451 D St., Suite 502, Boston, MA 02210 |
| Email: | mwawer@kojintx.com |
| Phone: | 617-952-0636 |
| Publications: | https://www.biorxiv.org/content/10.1101/2024.04.28.591561v1 |
Summary of all studies in project PR002077
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST003341 | Untargeted Lipidomic Profiling of Canine Cancer Cell Lines | Canis lupus familiaris | Kojin Therapeutics, Inc. | MS | 2024-09-12 | 1 | 62 | Uploaded data (3.9G)* |
