Summary of project PR002127
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR002127. The data can be accessed directly via it's Project DOI: 10.21228/M8PG19 This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR002127 |
| Project DOI: | doi: 10.21228/M8PG19 |
| Project Title: | Integration of Metabolomics and Transcriptomics Reveals Metabolic Characteristics and Potential Biomarker Involved in Radiation-Induced Liver Injury in a Rat Model. |
| Project Type: | MS quantitative analysis |
| Project Summary: | Radiation-induced liver damage (RILD) is a disease characterized by a series of physiological and pathological changes in liver tissue following exposure to a certain dose of radiation, and it is also a common complication of liver cancer and abdominal tumor radiotherapy. To date, the pathogenesis of RILD remains unclear, and effective diagnostic and therapeutic approaches are lacking. Based on this, the present study established an animal model of radiation-induced liver disease (RILD) using whole-liver irradiated rats. Metabolomics and transcriptomics were integrated to analyze liver tissue samples collected 7 days post-irradiation. The involved metabolic disorders primarily include ammonia metabolism, amino acid metabolism, glutathione metabolism and lipid metabolism. Moreover, a panel of potential plasma metabolic markers was identified through correlation analysis between liver tissue and plasma metabolic characteristics. Subsequently, the levels of radiation injury within 7 days post irradiation were assessed. This study provides experimental evidence for the identification of early diagnostic markers for whole-liver irradiation and RILD, as well as for exploring the molecular and pathophysiological mechanisms of RILD. |
| Institute: | Soochow University |
| Last Name: | Wang |
| First Name: | Chang |
| Address: | Suzhou, No. 199, Renai Road, Suzhou Industrial Park |
| Email: | wangchang@suda.edu.cn |
| Phone: | +86-512-65880067 |
Summary of all studies in project PR002127
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST003453 | Integration of Metabolomics and Transcriptomics Reveals Metabolic Characteristics and Potential Biomarker Involved in Radiation-Induced Liver Injury in a Rat Model. | Rattus norvegicus | Soochow University | MS | 2024-09-24 | 1 | 480 | Uploaded data (1.6G)* |
