Summary of project PR002133
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR002133. The data can be accessed directly via it's Project DOI: 10.21228/M8WZ5H This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR002133 |
| Project DOI: | doi: 10.21228/M8WZ5H |
| Project Title: | Impact of Cattle Feeding Systems on Beef and Human Post-prandial Metabolomics – A Randomized Clinical Trial |
| Project Summary: | Cattle feeding systems may have health implications for consumers of beef products. Organic grass-fed (GRA) and conventional (CON) cattle feeding systems may result in beef products with differing metabolite profiles, and therefore could impact the postprandial metabolomic response of consumers. This study aims to measure whole beef metabolomics and postprandial metabolomic response of consumers between GRA and CON beef to elucidate potential health implications. This study followed a double-blind, crossover design with healthy male and female subjects (n=10). Serum samples were taken at fasting (0) and postprandially for four hours after consumption of a steak from each condition. Untargeted metabolomic analysis of whole beef and human serum samples utilized LC/MS. Multivariate and pathway enrichment analysis in MetaboAnalyst was used to investigate metabolite and biochemical pathways that distinguished CON and GRA. Cattle feeding systems impacted both postprandial and whole beef steak metabolomic profiles. Metabolites that contributed to this variation included carnitine species (Proionylcarnitine), fatty acids, amino acids (L-Valine) and Calamendiol. These metabolites have been associated with oxidative stress, inflammation, and cardiovascular health. Functional pathway enrichment analysis revealed numerous amino acid degradation pathways, especially branched chain amino acids, and fatty acid degradation that changed throughout the postprandial time course. These findings suggest that CON and GRA cattle feeding systems differentially impact whole beef metabolomics, as well as consumer postprandial metabolic responses and the associated health implications. |
| Institute: | Montana State University |
| Last Name: | Cooper |
| First Name: | Gwendolyn |
| Address: | Culbertson Hall 100, Bozeman, Montana, 59717, USA |
| Email: | coopergwen823@gmail.com |
| Phone: | 9079037662 |
Summary of all studies in project PR002133
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST003474 | Impact of Cattle Feeding Systems on Beef and Human Postprandial Metabolomics – A Randomized Clinical Trial | Homo sapiens | Montana State University | MS* | 2024-09-27 | 1 | 213 | Uploaded data (3.8G)* |
