Summary of project PR002144

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR002144. The data can be accessed directly via it's Project DOI: 10.21228/M8GR8V This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

Project ID: PR002144
Project DOI:doi: 10.21228/M8GR8V
Project Title:Hepatocyte Period 1 dictates oxidative substrate selection independent of the core circadian clock
Project Summary:In this project we quantified the extent to which exogenously administered FGF21 reconstitutes substrate selection observed in fasting Per1iLKO mice. We treated Per1fl/fl or Per1iLKO mice with or without recombinant FGF21 protein after a 14 h + 2 h fast/refeed, and subjected them to heavy isotope metabolic tracing in vivo. Although we observed no significant defects found in total hepatic metabolites involved in glycolysis and PDH-mediated pathway in Per1iLKO mice during refeeding, [13C6]-glucose tracing revealed increased labeling in the glycolytic and PDH-mediated TCA cycle in fasting Per1iLKO mice. Moreover, treatment with recombinant FGF21 significantly reduced glycolytic and PDH-mediated TCA cycle flux in Per1iLKO mice, but did not drive significant changes in fasting Per1fl/fl mice.
Institute:Washington University in St. Louis
Last Name:Sun
First Name:Jiameng
Address:660 S. Euclid Ave
Email:jiameng@wustl.edu
Phone:3149349954

Summary of all studies in project PR002144

Study IDStudy TitleSpeciesInstituteAnalysis
(* : Contains Untargted data)		 Release
Date		VersionSamplesDownload
(* : Contains raw data)
ST003495 Hepatocyte Period 1 dictates oxidative substrate selection independent of the core circadian clock Mus musculus Washington University in St. Louis MS 2024-09-25 1 34 Uploaded data (501.5M)*
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