Summary of project PR002164
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR002164. The data can be accessed directly via it's Project DOI: 10.21228/M8WR6T This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR002164 |
| Project DOI: | doi: 10.21228/M8WR6T |
| Project Title: | Insulin mitigates acute ischemia induced atrial fibrillation and sinoatrial node dysfunction ex vivo |
| Project Summary: | Acute atrial ischemia is a well-known cause of postoperative atrial fibrillation (POAF). However, the mechanisms through which ischemia contributes to the development of POAF are not well understood. In this study, ex vivo Langendorff perfusion was employed to induce acute atrial ischemia and reperfusion in the heart, resulting in a temporary form of POAF. The likelihood of atrial fibrillation (AF) was evaluated using programmed electrical stimulation and confirmed through open-atrium optical mapping. Compared to the control group without ischemia, 25 minutes of ischemia significantly increased the incidence of AF. The right atrium was found to be more susceptible to AF than the left atrium. Administering insulin for 30 minutes before ischemia and during reperfusion after 25 minutes of ischemia greatly reduced the vulnerability to AF. Additionally, IC-MS was utilized to assess the effect of insulin on the metabolism of the ischemic and reperfused heart. |
| Institute: | Mayo Clinic |
| Last Name: | Zhu |
| First Name: | Wuqiang |
| Address: | 5951 E Mayo Blvd, RE 1-408, Zhu Lab, Phoenix, AZ 85054 |
| Email: | zhu.wuqiang@mayo.edu |
| Phone: | 480-301-9693 |
Summary of all studies in project PR002164
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST003519 | Effect of insluin on metabolism of ex vivo ischemia heart | Rattus norvegicus | Mayo Clinic | MS | 2024-11-04 | 1 | 10 | Uploaded data (1.7G)* |
