Summary of project PR002185
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR002185. The data can be accessed directly via it's Project DOI: 10.21228/M86527 This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR002185 |
| Project DOI: | doi: 10.21228/M86527 |
| Project Title: | Metabolomics analysis of tissues isolated from Aldh7a1+/+ and Aldh7a1-/- (KO) mice. |
| Project Type: | Manuscript |
| Project Summary: | ALDH7A1 is an enzyme involved in the catabolism of lysine. Using Aldh7a1-knockout (-/-) and wild-type (+/+) mice and metabolomics, we aim to determine how Aldh7a1-deficiency leads to the accumulation of lysine catabolites upstream of ALDH7A1 and affects other metabolic pathways. Our results suggest that there is a tissue-specific accumulation of lysine and other metabolites, with the brain exhibiting the largest number of significantly different metabolites. |
| Institute: | University of British Columbia |
| Department: | Biochemistry & Molecular Biology |
| Laboratory: | Parker laboratory |
| Last Name: | Parker |
| First Name: | Seth |
| Address: | 950 W 28th Ave, Vancouver, British Columbia, V6H 0B3, Canada |
| Email: | seth.parker@bcchr.ca |
| Phone: | 6048753121 |
Summary of all studies in project PR002185
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST003549 | Metabolomics analysis of kidney, brain, liver, and plasma from Aldh7a1-/- and Aldh7a1+/+ mice. | Mus musculus | University of British Columbia | MS | 2024-11-15 | 1 | 24 | Uploaded data (5.1G)* |
