Summary of project PR002202
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR002202. The data can be accessed directly via it's Project DOI: 10.21228/M80G0Q This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR002202 |
| Project DOI: | doi: 10.21228/M80G0Q |
| Project Title: | High mobility group A1 (HMGA1) promotes the tumorigenesis of colorectal cancer by increasing lipid synthesis |
| Project Type: | LC-MS |
| Project Summary: | Metabolic reprogramming is a hallmark of cancer, enabling tumor cells to meet the high energy and biosynthetic demands required for their proliferation. High mobility group A1 (HMGA1) is a structural transcription factor and frequently overexpressed in human colorectal cancer (CRC). Here, we show that HMGA1 promotes CRC progression by driving lipid synthesis in a AOM/DSS-induced CRC mouse model. Using conditional knockout (Hmga1△IEC) and knock-in (Hmga1IEC-OE/+) mouse models, we demonstrate that HMGA1 enhances CRC cell proliferation and accelerates tumor development by upregulating fatty acid synthase (FASN). Mechanistically, HMGA1 increases the transcriptional activity of sterol regulatory element-binding protein 1 (SREBP1) on the FASN promoter, leading to increased lipid accumulation in intestinal epithelial cells. Moreover, a high-fat diet exacerbates CRC progression in Hmga1△IEC mice, while pharmacological inhibition of FASN by orlistat reduces tumor growth in Hmga1IEC-OE/+ mice. Our findings suggest that targeting lipid metabolism could offer a promising therapeutic strategy for CRC. |
| Institute: | Henan University |
| Last Name: | Xu |
| First Name: | Zhi-Xiang |
| Address: | Jinming Road, Kaifeng, Henan province, 475000, China |
| Email: | zhixiangxu08@gmail.com |
| Phone: | 86-13270538760 |
Summary of all studies in project PR002202
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST003568 | Differentially regulated metabolites in intestinal epithelial cells from Hmga1flox/flox and Hmga1△IEC mice | Mus musculus | Henan University | MS* | 2024-12-02 | 1 | 6 | Uploaded data (764.5M)* |
| ST003569 | Differentially regulated metabolites in colorectal cancer from Rosa26Hmga1/+ and Hmga1IEC-OE/+mice | Mus musculus | Henan University | MS* | 2024-12-02 | 1 | 6 | Uploaded data (492.6M)* |
