Summary of project PR002226
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR002226. The data can be accessed directly via it's Project DOI: 10.21228/M8WG15 This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR002226 |
| Project DOI: | doi: 10.21228/M8WG15 |
| Project Title: | Nuclear Factor I A (NFIA) regulates articular chondrocyte fatty acid metabolism and joint homeostasis |
| Project Summary: | Osteoarthritis (OA) has recently been recognized as a joint disease with an etiology partially rooted in metabolic dysfunction, yet the underlying mechanism(s) in this context are not determined, limiting opportunities to develop therapeutic treatments. In this study, we utilized a multi-omics approach combining RNA-seq, ATAC-seq, MRE-seq, and metabolomics to reveal that OA articular chondrocytes induced by imbalanced Transforming Growth Factor β 1/Bone Morphogenetic Protein 2 (TGF-β/BMP) signaling, possess increased fatty acid synthesis and oxidation processes regulated by Nuclear Factor I A (NFIA) upregulation |
| Institute: | Washington University in St. Louis |
| Department: | Orthopaedic Surgery, Chemistry, Medicine |
| Laboratory: | Shen Laboratory and Patti Laboratory |
| Last Name: | Cho |
| First Name: | Kevin |
| Address: | 1 Brookings Drive |
| Email: | kevin.cho@wustl.edu |
| Phone: | 314-935-8813 |
Summary of all studies in project PR002226
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST003598 | Nuclear Factor I A (NFIA) Regulates Articular Chondrocyte Fatty Acid Metabolism and Joint Homeostasis | Mus musculus; Homo sapiens | Washington University in St. Louis | MS | 2025-07-21 | 1 | 48 | Uploaded data (717.6M)* |
