Summary of project PR002245
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR002245. The data can be accessed directly via it's Project DOI: 10.21228/M8F83T This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR002245 |
| Project DOI: | doi: 10.21228/M8F83T |
| Project Title: | Untargeted Lipidomics of African American women at 8-10 months postpartum |
| Project Type: | Untargeted Lipidomics with DDA |
| Project Summary: | Lipid dysregulation is hallmark of CMCPreg, specifically polyunsaturated fatty acids (PUFA) metabolism and downstream lipid mediators. To investigate whether this lipid dysregulation is prolonged after delivery, we performed untargeted lipidomics on serum collected 8-10 months postpartum from African American women who were diagnosed with cardiometabolic complications of pregnancy and from those with uncomplicated, term deliveries. We identified 11 lipids that were significantly increased in the postpartum serum of African American women who experienced cardiometabolic complications of pregnancy. These species belonged to sphingolipid, glycerolipid, and cholesteryl ester lipid classes and reveal dysregulated activity of glycerophospholipid metabolism, sphingolipid metabolism, sphingolipid signaling pathways, ferroptosis, and others by lipid enrichment pathway analysis. We also observed increases in Resolvin D3, 13 HpODE, AEA, OEA, and LEA suggesting dysregulated endocannabinoid signaling and increased phospholipaseA2 activity. Combined, these findings demonstrate that African American women who experienced cardiometabolic complications of pregnancy may have dysregulated lipid metabolism that extends as long as 8-10 months postpartum. |
| Institute: | Emory University |
| Last Name: | Maner-Smith |
| First Name: | Kristal |
| Address: | 1750 Haygood Dr. Office N256 Atlanta, GA 30322 |
| Email: | kmaners@emory.edu |
| Phone: | 4047273193 |
| Funding Source: | NIH |
| Publications: | PMID 38668319 |
Summary of all studies in project PR002245
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST003632 | Dysregulated Lipid Metabolism in African American Women Who Experienced Cardiometabolic Complications of Pregnancy | Homo sapiens | Emory University | MS | 2025-11-26 | 1 | 32 | Uploaded data (5.5G)* |
