Summary of project PR002248
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR002248. The data can be accessed directly via it's Project DOI: 10.21228/M8224Q This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR002248 |
| Project DOI: | doi: 10.21228/M8224Q |
| Project Title: | Intracellular and supernatant metabolomes of ferroptotic Pfa1 cells using HPLC-MS/MS |
| Project Summary: | In order to investigate metabolites both secreted from and enriched in cells upon ferroptotic cell death, we compared metabolomes from supernatants and lysates of ferroptotic to nonferroptotic Pfa1 cells after 24 h(cells are alive), 30 h (ferroptosis is present) as well as supernatants after 72 h (no cells left). In Pfa1 cells, ferroptosis is induced upon treatment with tamoxifen which induces knock-out of GPX4, causing massive ferroptosis. Ferroptosis, in turn, was rescued using lipid ros scavenger FER-1 (Ferrostatin1). |
| Institute: | Cecad |
| Last Name: | Seidel |
| First Name: | Eric |
| Address: | Joseph-Stelzmann-Str. 26, Cologne, NRW, D-50931, Germany |
| Email: | eric.seidel@uk-koeln.de |
| Phone: | +4902118184372 |
Summary of all studies in project PR002248
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST003635 | Intracellular and supernatant metabolomes of ferroptotic Pfa1 cells using HPLC-MS/MS | Mus musculus | CECAD Research Center | MS | 2024-12-31 | 1 | 124 | Uploaded data (24G)* |
