Summary of project PR002251
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR002251. The data can be accessed directly via it's Project DOI: 10.21228/M8NV72 This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR002251 |
| Project DOI: | doi: 10.21228/M8NV72 |
| Project Title: | The Spatial Transcriptional Activity of Hepatic TCF7L2 Regulates Zonated Metabolic Pathways that Contribute to Liver Fibrosis |
| Project Summary: | Study used single nuclei genomics techniques to examine the spatial transcriptional function of the transcription factor 7-like 2 (TCF7L2) in rodent liver. Research aimed to determine the consequences of TCF7L2 transcriptional inactivation on the metabolic architecture of the liver, and on the function of key zonated metabolic pathways that influence the development of fibrotic liver diseases. Dietary stress was investigated using the Gubra Amylin Nash (GAN) and choline-deficient amino acid-defined high fat (CDAHFD) diets to investigate the susceptibility of liver-specific TCF7L2 mutant mice (Hep-TCF7L2ΔDBD) compared to control (TCF7L2LoxP/LoxP) mice in hepatic fibrosis. |
| Institute: | UT Health San Antonio |
| Last Name: | Norton |
| First Name: | Luke |
| Address: | 7703 Floyd Curl Drive, San Antonio, TX 78229 |
| Email: | nortonl@uthscsa.edu |
| Phone: | (210)-567-0739 |
Summary of all studies in project PR002251
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST003641 | The Spatial Transcriptional Activity of Hepatic TCF7L2 Regulates Zonated Metabolic Pathways that Contribute to Liver Fibrosis | Mus musculus | UT Health San Antonio | MS | 2025-01-06 | 1 | 48 | Uploaded data (30.2M)* |
