Summary of project PR002254
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR002254. The data can be accessed directly via it's Project DOI: 10.21228/M88J99 This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR002254 |
| Project DOI: | doi: 10.21228/M88J99 |
| Project Title: | Acetyl-CoA synthesis in the skin is a key determinant of systemic lipid homeostasis |
| Project Type: | MS quantitative analysis |
| Project Summary: | ATP-citrate lyase (ACLY) generates cytosolic acetyl-CoA for lipid synthesis and is a promising therapeutic target in diseases with altered lipid metabolism. Here, we developed inducible whole-body Acly knockout mice to determine the requirement for ACLY in normal tissue functions, uncovering its crucial role in skin homeostasis. ACLY-deficient skin upregulates the acetyl-CoA synthetase ACSS2; deletion of both Acly and Acss2 from the skin exacerbates skin abnormalities, with differential effects on two major lipid-producing skin compartments. While the epidermis is depleted of barrier lipids, the sebaceous glands increase production of sebum, supplied at least in part by circulating fatty acids and coinciding with adipose lipolysis and fat depletion. Dietary fat supplementation further boosts sebum production and partially rescues both the lipoatrophy and aberrant skin phenotypes. The data establish a critical role for cytosolic acetyl-CoA synthesis in maintaining skin barrier integrity and highlight the skin as a key organ in systemic lipid regulation. |
| Institute: | University of Pennsylvania |
| Department: | Cancer Biology |
| Laboratory: | Wellen |
| Last Name: | Nguyen |
| First Name: | Phuong |
| Address: | 421 Curie Boulevard, Philadelphia, Pennsylvania, 19104, USA |
| Email: | pttnguyen27@gmail.com |
| Phone: | 2674376821 |
| Publications: | Nguyen, P. et al Acetyl-CoA synthesis in the skin is a key determinant of systemic lipid homeostasis |
Summary of all studies in project PR002254
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST003644 | Mouse epidermal lipidomics | Mus musculus | University of Pennsylvania | MS* | 2025-01-13 | 1 | 40 | Uploaded data (619.2M)* |
