Summary of project PR002287
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR002287. The data can be accessed directly via it's Project DOI: 10.21228/M80Z5F This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR002287 |
| Project DOI: | doi: 10.21228/M80Z5F |
| Project Title: | The childhood salivary metabolome reflects inter-individual variation in weight status, lifestyle, and mental wellbeing |
| Project Type: | (Un)targeted MS |
| Project Summary: | Saliva is an emerging biofluid in metabolomics as it provides a similar window into biological information as blood, while enabling repetitive and non-invasive sampling. Here, the salivary metabolome of 965 children (7-17y) from 2 European countries was comprehensively analyzed using ultra-high performance liquid chromatography coupled to high-resolution mass spectrometry providing >3,500 untargeted features and 188 consistently detected metabolites. Correlation analysis with anthropometric, mental wellbeing, lifestyle and dietary data revealed that weight status and age reflected the salivary metabolome best, with functional analysis demonstrating alterations in multiple pathways. These findings were replicated in 2 validation cohorts involving 471 children (8-18y) confirming previously reported blood biomarkers and new molecules. For example, acesulfame K, an artificial sweetener detected in all cohorts, increased with weight and mental distress, while correlating to specific food/beverage consumption. Our data offer a high-quality repository of the pediatric salivary metabolome for providing guidance in exploring its association with children's health. |
| Institute: | Ghent University |
| Department: | Department of Translational Physiology, Infectiology and Public Health |
| Laboratory: | Laboratory of Integrative Metabolomics |
| Last Name: | callemeyn |
| First Name: | emile |
| Address: | Salisburylaan 133, 9820, Merelbeke, Belgium |
| Email: | emile.callemeyn@ugent.be |
| Phone: | 0032473271636 |
| Funding Source: | Fonds Wetenschappelijk Onderzoek |
Summary of all studies in project PR002287
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST003687 | Cross-sectional salivary metabolomics of the Fin-HIT corhort | Homo sapiens | Ghent University | MS* | 2025-07-07 | 1 | 1164 | Uploaded data (4.7G)* |
| ST003697 | Cross-sectional salivary metabolomics of the FAME cohort (children 11-17 years) | Homo sapiens | Ghent University | MS* | 2025-07-07 | 1 | 610 | Uploaded data (45.9G)* |
| ST003706 | Cross-sectional salivary metabolomics of the OPERA corhort | Homo sapiens | Ghent University | MS* | 2025-07-07 | 1 | 164 | Uploaded data (1.7G)* |
| ST003709 | Cross-sectional salivary metabolomics of the PANIC cohort (children 11-17 years) | Homo sapiens | Ghent University | MS* | 2025-07-07 | 1 | 354 | Uploaded data (7.8G)* |
