Summary of project PR002298
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR002298. The data can be accessed directly via it's Project DOI: 10.21228/M8KR8S This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR002298 |
| Project DOI: | doi: 10.21228/M8KR8S |
| Project Title: | NAD Depletion in Skeletal Muscle does not Compromise Muscle Function or Accelerate Aging |
| Project Summary: | NAD is a ubiquitous electron carrier essential for energy metabolism and the posttranslational modification of numerous regulatory proteins. Perturbation of NAD metabolism is considered detrimental to health, with NAD depletion commonly thought to promote aging. However, the extent to which cellular NAD concentration can be decreased without deleterious repercussions is unclear. We generated a mouse model where nicotinamide phosphoribosyltransferase (NAMPT)-mediated NAD+ biosynthesis is disrupted in adult skeletal muscle. The resulting 85% decrease in muscle NAD+ abundance was associated with preserved tissue integrity and functionality, as demonstrated by its unchanged morphology, contractility, and exercise tolerance. This lack of defects was corroborated by intact mitochondrial respiratory capacity and unaffected muscle transcriptomic and proteomic profiles. Furthermore, lifelong NAD depletion did not accelerate muscle aging or impair whole-body metabolism. Collectively, these findings indicate that NAD depletion does not contribute to age related declines in skeletal muscle function. This submission contains lipidomics data. |
| Institute: | University of Copenhagen |
| Department: | Novo Nordisk Foundation Center for Basic Metabolic Research |
| Laboratory: | TREEBAK GROUP |
| Last Name: | Treebak |
| First Name: | Jonas Thue |
| Address: | Blegdamsvej 3B, Mærsk Tårnet, 7. sal 2200 København N. |
| Email: | jttreebak@sund.ku.dk |
| Phone: | +4524805398 |
Summary of all studies in project PR002298
| Study ID | Study Title | Species | Institute | Analysis (* : Contains Untargted data) |
Release Date | Version | Samples | Download (* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST003703 | NAD Depletion in Skeletal Muscle does not Compromise Muscle Function or Accelerate Aging | Mus musculus | University of Copenhagen | MS | 2025-02-24 | 1 | 51 | Uploaded data (10.4G)* |
